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Titanium for Biomedical Applications

by Gabriel ConstantinescuonNovember 18, 2019

Some alloys like Ni14Ti11 (Nitinol, a well-known shape memory alloy) have received a lot of attention in magnetic resonance imaging (MRI) diagnostic tools. Currently, Nitinol stents are often used in the treatment of cardiovascular disease and are usually coated with a thin film of carbon, in order to enhance blood compatibility.

The clinical goal and most critical factor in the success of bone implants (orthopaedics and dentistry) is to achieve osseointegration, particularly by establishing a strong and long-lasting structural and functional connection between the artificial implant surface and peri-implant living bone, leading to a stable mechanical attachment of the implant at the site of implantation.

Osseointegration is defined as direct contact on the light microscopic level between living bone tissue and the implant. Using titanium screw dental implants in the jaw, a lasting interface under loaded conditions extending over a 20-year follow-up period has been demonstrated. This demonstration brings up the question whether a similar interface can be achieved in total hip arthroplasty (THA) between living bone and a titanium alloy implant under necessitated conditions of immediate loading.

Osseointegration is crucial to be achieved as fast as possible, because it assures the successful long-term integration of the implant into the body, without being rejected by it. It’s as if the implant is a foreigner wanting to be part of a family. Through osseointegration, it ‘gains the trust of the family’ and thus becomes an ‘official’ member of it, enjoying all the benefits that come from this union. And the faster he does this, of course, the better.

Therefore, the fate of the implant material is not only governed by the bulk, but also by its surface properties (surface chemistry, morphology and structure), which are crucial factors in the interactions with the surrounding tissues from the body.

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